Thesis
Application of magnetic resonance for non-invasive phenotyping of mice with altered metabolism
- Abstract:
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Changes in myocardial energetics have been implicated in the pathophysiology of heart failure (HF). However, the precise contribution of creatine (Cr) / phosphocreatine (PCr) / creatine kinase (CK) energy buffer and transfer remains unclear. The aim of this thesis was to study the effects on murine cardiac function of both impairment and enhancement of creatine metabolism.
In order to longitudinally follow the cause and effect relationship of myocardial creatine concentration, a non...
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Authors
Contributors
+ Neubauer, S
Role:
Supervisor
+ Schneider, J
Role:
Supervisor
+ Lygate, C
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:73d1b728-b9e5-41fa-999f-30025b70d25e
- Local pid:
- ora:7709
- Deposit date:
- 2014-02-03
Terms of use
- Copyright holder:
- Kiterie M E Faller
- Copyright date:
- 2013
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