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Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae

Abstract:

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move between genetic lineages is an open question, which we address in the context of antibiotic resistance in Streptococcus pneumoniae . We analyze microbiological, genomic and epidemiological data from the largest-to-date sequenced pneumococcal carriage study in 955 infants from a refugee camp on the Thailand-Myanmar border. Using a unified framework, we simultaneously test prior h...

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Publication status:
Not published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/656751

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
BDI-NDM
Role:
Author
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Role:
Author
ORCID:
0000-0002-1313-4011
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Publication date:
2019-06-11
DOI:
Source identifiers:
1023051
Pubs id:
pubs:1023051
UUID:
uuid:73e19f78-3d72-4992-9997-8fa63ee69ee7
Local pid:
pubs:1023051
Deposit date:
2019-08-01

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