Journal article
The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+
- Abstract:
-
Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is a lethal genetic disease causing arrhythmias and sudden cardiac death in children and young adults and is linked to mutations in the cardiac ryanodine receptor (RyR2). The effects of CPVT1 mutations on RyR2 ion-channel function are often investigated using purified recombinant RyR2 channels homozygous for the mutation. However, CPVT1 patients are heterozygous for the disease, so this approach does not reveal the true c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
PG/19/38/34403
PG/19/67/34607
RG/10/14/28576
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Physiology Journal website
- Volume:
- 599
- Issue:
- 23
- Pages:
- 5179-5201
- Publication date:
- 2021-11-09
- Acceptance date:
- 2021-09-30
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- Pmid:
-
34676560
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1206222
- Local pid:
- pubs:1206222
- Deposit date:
- 2022-03-12
Terms of use
- Copyright holder:
- Wilson et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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