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A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

Abstract:

Many bacteria use a type III secretion system to inject effector proteins into host cells. Selection and export of the effectors is controlled by a set of soluble proteins at the cytosolic interface of the membrane spanning type III secretion “injectisome”. Combining fluorescence microscopy, biochemical interaction studies and fluorescence correlation spectroscopy, we show that in live Yersinia enterocolitica bacteria these soluble proteins form complexes both at the injectisome and in t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms15940

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Sezgin, E
Grant:
Marie Curie Intra-European Fellowship (MEMBRANE DYNAMICS
More from this funder
Funding agency for:
Sezgin, E
Grant:
Marie Curie Intra-European Fellowship (MEMBRANE DYNAMICS
More from this funder
Funding agency for:
Sezgin, E
Grant:
Marie Curie Intra-European Fellowship (MEMBRANE DYNAMICS
More from this funder
Funding agency for:
Sezgin, E
Grant:
Marie Curie Intra-European Fellowship (MEMBRANE DYNAMICS
More from this funder
Funding agency for:
Sezgin, E
Grant:
Marie Curie Intra-European Fellowship (MEMBRANE DYNAMICS
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Article number:
15940
Publication date:
2017-06-27
Acceptance date:
2017-05-15
DOI:
ISSN:
2041-1723
Source identifiers:
695960
Pubs id:
pubs:695960
UUID:
uuid:74290d0a-7049-4831-816d-1d8ead6b91b7
Local pid:
pubs:695960
Deposit date:
2017-05-19

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