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MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

Abstract:

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are activated during infection, an effect maintained even after antibiotic treatment. At the peak of infection MAIT cell T-cell receptor (TCR)β clonotypes that are over-represented prior to infection transiently contract. Select MAIT cell TCRβ cl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-02540-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0003-3522-4533
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Article number:
253
Publication date:
2018-01-17
Acceptance date:
2017-12-07
DOI:
ISSN:
2041-1723
Source identifiers:
821035
Language:
English
Pubs id:
pubs:821035
UUID:
uuid:746818be-2be3-43bc-a3ef-326fc000eb40
Local pid:
pubs:821035
Deposit date:
2018-01-25

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