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An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.

Abstract:

Promiscuous expression of tissue-restricted auto-antigens in the thymus imposes T-cell tolerance and provides protection from autoimmune diseases. Promiscuous expression of a set of self-antigens occurs in medullary thymic epithelial cells and is partly controlled by the autoimmune regulator (AIRE), a nuclear protein for which loss-of-function mutations cause the type 1 autoimmune polyendocrine syndrome. However, additional factors must be involved in the regulation of this promiscuous expres...

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Publication status:
Published

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Publisher copy:
10.1038/nature06066

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Journal:
Nature
Volume:
448
Issue:
7156
Pages:
934-937
Publication date:
2007-08-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
243141

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