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Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package

Version:
1

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Creator, Researcher

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI)
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Department:
Diamond Light Source (DLS)
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
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Publisher:
University of Oxford
Publication date:
2018
Version number:
1
DOI:
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
UUID:
uuid:749c0065-57e3-4860-8eea-5d351a859246
Deposit date:
2018-04-09

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