Thesis
The role of NLRs in induction and resolution of intestinal inflammation
- Abstract:
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Innate immune activation is thought to play a central role in IBD pathogenesis because genetic polymorphisms in NOD2 and NLRP3, cytosolic innate immune receptors belonging to the NLR family, have been associated with IBD susceptibility. However, the mechanisms through which NLR mutations predispose to IBD remain unclear. The aim of this project was to dissect the functional roles of different NLRs in intestinal inflammation. Using the well-established DSS-induced colitis model as well as e...
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Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:74c0e3a2-82ae-4311-8abe-21926835bc17
- Local pid:
- ora:7507
- Deposit date:
- 2013-10-24
Terms of use
- Copyright holder:
- George Song-Zhao
- Copyright date:
- 2012
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