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Journal article

111In-BnDTPA-F3: an Auger electron-emitting radiotherapeutic agent that targets nucleolin.

Abstract:

INTRODUCTION: The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membrane of some cancer cells. The goal was to investigate the use of 111In-labeled F3 peptide for Auger electron-targeted radiotherapy. METHODS: F3 was labeled with fluorescein isothiocyanate (FITC) for confocal microscopy and conjugated to p-SCN-benzyl-diethylenetriaminepentaa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/2191-219x-2-9

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Gray Cancer Institute
Role:
Author
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CR-UK/EPSRC Oxford Cancer Imaging Centre More from this funder
Cancer Research UK More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
SpringerOpen Publisher's website
Journal:
EJNMMI research Journal website
Volume:
2
Issue:
1
Pages:
9
Publication date:
2012-01-01
DOI:
EISSN:
2191-219X
ISSN:
2191-219X
Source identifiers:
312834
Language:
English
Keywords:
Pubs id:
pubs:312834
UUID:
uuid:74caf8fc-5958-4418-9b6b-456d7c40d26b
Local pid:
pubs:312834
Deposit date:
2012-12-19

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