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Population pharmacokinetic and pharmacodynamic modeling of artemisinin resistance in Southeast Asia

Abstract:

Orally administered artemisinin-based combination therapy is the first-line treatment against uncomplicated P. falciparum malaria worldwide. However, the increasing prevalence of artemisinin resistance is threatening efforts to treat and eliminate malaria in Southeast Asia. This study aimed to characterize the exposure-response relationship of artesunate in patients with artemisinin sensitive and resistant malaria infections. Patients were recruited in Pailin, Cambodia (n = 39), and Wang Pha,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1208/s12248-017-0141-1

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
Li Ka Shing Foundation More from this funder
Wellcome Trust More from this funder
US Agency for International Development More from this funder
Publisher:
Springer US Publisher's website
Journal:
AAPS Journal Journal website
Volume:
19
Issue:
6
Pages:
1842–1854
Publication date:
2017-09-11
Acceptance date:
2017-08-23
DOI:
ISSN:
1550-7416
Source identifiers:
724018
Keywords:
Pubs id:
pubs:724018
UUID:
uuid:753573e2-bbec-4d59-8b22-c02213e399f6
Local pid:
pubs:724018
Deposit date:
2017-08-24

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