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Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus Infection.

Abstract:

The treatment of HCV infection has seen significant progress, particularly since the approval of new direct-acting antiviral drugs. However these clinical achievements have been made despite an incomplete understanding of HCV replication and within-host evolution, especially compared with HIV-1. Here, we undertake a comprehensive analysis of HCV within-host evolution during chronic infection by investigating over 4000 viral sequences sampled longitudinally from 15 HCV-infected patients. We co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1005894

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
Raghwani, J
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
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Funding agency for:
Pybus, O
Grant:
(FP7/2007-2013)ERC no. 614725-PATHPHYLODYN
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
12
Issue:
9
Pages:
e1005894
Publication date:
2016-09-15
Acceptance date:
2016-08-24
DOI:
ISSN:
1553-7366 and 1553-7374
Pmid:
27631086
Source identifiers:
645952
Language:
English
Keywords:
Pubs id:
pubs:645952
UUID:
uuid:75399da7-1425-496c-aec3-6f0ed08fd3ab
Local pid:
pubs:645952
Deposit date:
2016-09-26

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