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Patterns of Host Genome—Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever

Abstract:

Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle— and endoplasmic reticulum (ER)—related genes, suggesting a proliferative response accompanied by ER stress. Transcript-abundance levels for immunoresponse-associated genes, including cell surface markers, immunoglobulin, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1086/512162

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
St Anne's College
Role:
Author
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/Wellcome Trust More from this funder
074636/Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
JournalName Journal website
Volume:
195
Issue:
8
Pages:
1097-1107
Publication date:
2007-04-15
Acceptance date:
2006-11-10
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
17357045
Source identifiers:
33785

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