Thesis icon

Thesis

Assembly of nucleic acids with site-specific modifications

Abstract:

The ability to synthesise large nucleic acids with site-specific chemical modifications would be invaluable for applications including therapeutics, epigenetics, and nanotechnology. Current approaches mainly rely on polymerase enzymes or solid-phase chemical synthesis, both of which have their limitations. The former is restricted to enzyme-tolerated modifications and cannot achieve site-specificity beyond the level of Watson-Crick base pairing; the latter is constrained to oligonucleotide...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Linacre College
Role:
Author

Contributors

Department:
Chemistry
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:7589baab-93b6-420e-b7e7-2e57f855a362
Deposit date:
2019-06-03

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP