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Maturing human CD127+ CCR7+ PDL1+ dendritic cells express AIRE in the absence of tissue restricted antigens

Abstract:

Expression of the Autoimmune regulator (AIRE) outside of the thymus has long been suggested in both humans and mice, but the cellular source in humans has remained undefined. Here we identify AIRE expression in human tonsils and extensively analyzed these “extra-thymic AIRE expressing cells” (eTACs) using combinations of flow cytometry, CyTOF and single cell RNA-sequencing. We identified AIRE+ cells as dendritic cells (DCs) with a mature and migratory phenotype including high levels of antige...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2018.02902

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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Article number:
2902
Publication date:
2019-01-14
Acceptance date:
2018-11-27
DOI:
EISSN:
1664-3224
Source identifiers:
966648
Keywords:
Pubs id:
pubs:966648
UUID:
uuid:760a108d-be37-48c5-a655-5104b731d525
Local pid:
pubs:966648
Deposit date:
2019-02-10

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