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Journal article

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing.

Abstract:

The 1000 Genomes Project and disease-specific sequencing efforts are producing large collections of haplotypes that can be used as reference panels for genotype imputation in genome-wide association studies (GWAS). However, imputing from large reference panels with existing methods imposes a high computational burden. We introduce a strategy called 'pre-phasing' that maintains the accuracy of leading methods while reducing computational costs. We first statistically estimate the haplotypes fo...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2354

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Nature genetics
Volume:
44
Issue:
8
Pages:
955-959
Publication date:
2012-08-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
344169
Language:
English
Keywords:
Pubs id:
pubs:344169
UUID:
uuid:760df042-2cf8-4e23-9f94-5c577568f1c2
Local pid:
pubs:344169
Deposit date:
2013-11-16

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