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Thesis

The role of StAR-D3 in HER2 overexpressing breast cancer

Abstract:

Background: HER2 overexpression in breast cancer is associated with poor prognosis. Trastuzumab is an anti-HER2 therapy and its clinical benefits have been established both in metastatic and early disease. However, Trastuzumab resistance is a common problem, even for patients who initially respond to the treatment. StAR-D3 gene is localized on the 17q12 amplicon and it is co-amplified with HER2. The contribution of StAR-D3 in HER2 positive breast cancer and its effect on Trastuzumab treatm...

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Institution:
University of Oxford
Division:
MSD
Research group:
Molecular Oncology
Oxford college:
St Peter's College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
Division:
MSD
Department:
Oncology
Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:7610268d-82e4-4564-a884-be4e2b95d833
Deposit date:
2016-11-15

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