Journal article
KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage
- Abstract:
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The p53 tumor suppressor protein plays a critical role in orchestrating the genomic response to various stress signals by acting as a master transcriptional regulator. Differential gene activity is controlled by transcription factors but also dependent on the underlying chromatin structure, especially on covalent histone modifications. After screening different histone lysine methyltransferases and demethylases, we identified JMJD2B/KDM4B as a p53-inducible gene in response to DNA damage. p53...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 8.0MB)
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- Publisher copy:
- 10.1093/nar/gkw1281
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Authors
Funding
NCI NIH HHS
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic Acids Research Journal website
- Volume:
- 45
- Issue:
- 7
- Pages:
- 3674-3692
- Publication date:
- 2017-01-10
- Acceptance date:
- 2016-12-12
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Pmid:
-
28073943
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
958452
- Local pid:
- pubs:958452
- Deposit date:
- 2021-02-18
Terms of use
- Copyright holder:
- Castellini et al.
- Copyright date:
- 2017
- Rights statement:
- ©2017, The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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