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KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage

Abstract:

The p53 tumor suppressor protein plays a critical role in orchestrating the genomic response to various stress signals by acting as a master transcriptional regulator. Differential gene activity is controlled by transcription factors but also dependent on the underlying chromatin structure, especially on covalent histone modifications. After screening different histone lysine methyltransferases and demethylases, we identified JMJD2B/KDM4B as a p53-inducible gene in response to DNA damage. p53...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkw1281

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Role:
Author
ORCID:
0000-0002-3069-0378
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
7
Pages:
3674-3692
Publication date:
2017-01-10
Acceptance date:
2016-12-12
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
28073943

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