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Journal article

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells

Abstract:

T cell senescence is thought to contribute to immune function decline, but the pathways that mediate senescence in these cells are not clear. Here, we evaluated T cell populations from healthy volunteers and determined that human CD8+ effector memory T cells that reexpress the naive T cell marker CD45RA have many characteristics of cellular senescence, including decreased proliferation, defective mitochondrial function, and elevated levels of both ROS and p38 MAPK. Despite their apparent sene...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci75051

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Funding agency for:
Puleston, D
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of clinical investigation Journal website
Volume:
124
Issue:
9
Pages:
4004-4016
Publication date:
2014-09-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
479842

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