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Journal article

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa

Abstract:

Background

The first models of malaria transmission assumed a completely mixed and homogeneous population of parasites. Recent models include spatial heterogeneity and variably mixed populations. However, there are few empiric estimates of parasite mixing with which to parametize such models.

Methods

Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio-temporal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.12688/wellcomeopenres.10784.1

Authors


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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
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Grant:
MRC/DFID Concordat agreement
Gottfied und Julia Bangerter-Rhyner Stiftung More from this funder
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Publisher:
Wellcome Trust Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
2
Pages:
10
Publication date:
2017-02-14
Acceptance date:
2017-02-14
DOI:
EISSN:
2398-502X
Pubs id:
pubs:700924
URN:
uri:76bd268d-aeac-4b49-93fc-6c864f82d20b
UUID:
uuid:76bd268d-aeac-4b49-93fc-6c864f82d20b
Local pid:
pubs:700924

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