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Thesis

The role of DOCK8 in the maintenance of CD8+ T cell memory and invariant NKT cells

Abstract:

The use of genome wide ENU mutagenesis screening has uncovered vast numbers of novel genes involved in the control of the immune system. This thesis describes the characterization of a novel mutant, Captain Morgan (CPM), originally identified in an immunization screen designed to evaluate both the initial antibody response to antigen and the ability to sustain antibody production. Mapping of this mutant lead to the identification of a single base pair mutation in a novel guanine n...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Prof. Richard Cornall
Oxford college:
Linacre College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
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Funding agency for:
Crawford, G
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:771febbe-ec6e-4e7b-9b6e-35b95d040b1a
Local pid:
ora:7185
Deposit date:
2013-08-15

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