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Understanding the role of NOS1AP on ECG parameters and arrhythmogenesis: insights from mice and men

Abstract:

Of the parameters on a surface ECG, the QT interval, which represents ventricular repolarisation, has arguably been the most studied. In humans, observational data suggests both short and long QT intervals are associated with a higher risk of ventricular and atrial arrhythmias. However, these observational studies are subject to limitations such as confounding and reverse causality, so the causal relevance is unclear. Unexpectedly, the strongest common non-coding genetic variants associate...

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Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
ORCID:
0000-0001-8140-7782
Institution:
University of Oxford
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
Role:
Examiner
ORCID:
0000-0001-8453-6133
Role:
Examiner
More from this funder
Programme:
Clinical Research Training Fellowship
Funding agency for:
Casadei, B
Gajendragadkar, PR
Grant:
FS/17/17/32438
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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