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Thesis

The function of NOD2 in antigen presenting cells

Abstract:

Crohn’s disease (CD), a chronic inflammatory condition of the gut affecting 1:1000 of western populations, is thought to arise from a dysregulated immune response in a genetically susceptible individual. Polymorphisms in the ligand recognition domain of an intracellular pattern recognition receptor (PRR), NOD2, remain the strongest genetic risk factor for the development of CD. NOD2 directs autophagy in human DCs to facilitate bacterial destruction and antigen presentation; the CD-variant-...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
"Simmons Group","HIU/TGU"
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
Biomedical Services
Role:
Supervisor
Division:
MSD
Department:
Biomedical Services
Role:
Supervisor
More from this funder
Funding agency for:
Allan, P
Grant:
RPKS0
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:773bf1c0-5dc6-40b7-97a1-9e70efdee1ae
Local pid:
ora:6948
Deposit date:
2013-07-05

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