Journal article icon

Journal article

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Abstract:

Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms. Here we present the structure of human PC2 in a closed conformation, solved by electron cryomicroscopy at 4.2-Å resolution. The structure reveals a novel polycystin-specific 'tetragonal opening for polycystins' (TOP) domain tightly bound to the top of a classic transient receptor potential (TRP) channel structure. The TOP do...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/nsmb.3343

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Sitsapesan, R
Grant:
RG/10/14/28576
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Structural and Molecular Biology Journal website
Volume:
24
Issue:
2
Pages:
114–122
Publication date:
2016-12-19
Acceptance date:
2016-11-14
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Source identifiers:
666790
Language:
English
Keywords:
Pubs id:
pubs:666790
UUID:
uuid:77bb905e-786d-46df-b614-d574073dc037
Local pid:
pubs:666790
Deposit date:
2016-12-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP