Journal article
Argonaute utilization for miRNA silencing is determined by phosphorylation-dependent recruitment of LIM-domain-containing proteins.
- Abstract:
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As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by binding both proteins simultaneously at distinct interfaces. Phosphorylation of AGO2 at Ser 387 by Akt3 induces LIMD1 binding, which in turn enables AGO2 to interact with TNRC6A and downstream effect...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.7MB)
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- Publisher copy:
- 10.1016/j.celrep.2017.06.027
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 20
- Issue:
- 1
- Pages:
- 173-187
- Publication date:
- 2017-07-05
- Acceptance date:
- 2017-06-09
- DOI:
- ISSN:
-
2211-1247
- Pmid:
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28683311
- Source identifiers:
-
707987
Item Description
Terms of use
- Copyright holder:
- Aboobaker et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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