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Argonaute utilization for miRNA silencing is determined by phosphorylation-dependent recruitment of LIM-domain-containing proteins.

Abstract:

As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by binding both proteins simultaneously at distinct interfaces. Phosphorylation of AGO2 at Ser 387 by Akt3 induces LIMD1 binding, which in turn enables AGO2 to interact with TNRC6A and downstream effect...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2017.06.027

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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
1
Pages:
173-187
Publication date:
2017-07-05
Acceptance date:
2017-06-09
DOI:
ISSN:
2211-1247
Pmid:
28683311
Source identifiers:
707987
Language:
English
Keywords:
Pubs id:
pubs:707987
UUID:
uuid:780809ea-6bf9-461e-a1fd-b3367ed2c1e5
Local pid:
pubs:707987
Deposit date:
2017-08-26

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