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Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling

Abstract:

Previously we proposed that transmission of the Hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling system that can cause birth defects and cancer? Using toxin-based sensors that distinguish between distinct pools of cholesterol, we find that Smoothened activation and Hedgehog signaling are driven by a biochemically-defined, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.50051

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Role:
Author
ORCID:
0000-0002-7344-8231
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Funding agency for:
Siebold, C
Grant:
647278
More from this funder
Funding agency for:
Siebold, C
Grant:
647278
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Article number:
e50051
Publication date:
2019-10-28
Acceptance date:
2019-10-25
DOI:
ISSN:
2050-084X
Pmid:
31657721
Source identifiers:
1069055
Language:
English
Keywords:
Pubs id:
pubs:1069055
UUID:
uuid:78143744-3e4b-4d03-8e19-781a285051e4
Local pid:
pubs:1069055
Deposit date:
2019-11-05

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