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Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

Abstract:

Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therapies and medical devices. Current models present inconsistencies with experimental data, which limit further progress. In this study, we present the design, development, calibrati...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.48890

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-0157-4386
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Institution:
University of Oxford
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Computer Science
Role:
Author
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Grant:
Archer RAP award (322 00180
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Issue:
2019
Article number:
e48890
Publication date:
2019-12-23
Acceptance date:
2019-12-18
DOI:
EISSN:
2050-084X
Pmid:
31868580
Source identifiers:
1078915
Language:
English
Keywords:
Pubs id:
pubs:1078915
UUID:
uuid:78459221-8eb5-4a40-b232-940a3f61d164
Local pid:
pubs:1078915
Deposit date:
2019-12-30

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