Journal article icon

Journal article

Squaramide‐based 5’‐phosphate replacements bind to the DNA repair exonuclease SNM1A

Abstract:

Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in therapeutics and in biological tools. We present the synthesis of N‐oxyamide and squaramide modifications at the 5’‐end of oligonucleotides as phosphate replacements and their biological evaluation using the 5’‐exonuclease SNM1A. The squaryl diamide modification showed minim...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/slct.201803375

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Expand authors...
Royal Society of Chemistry More from this funder
Trinity College Dublin More from this funder
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
ChemistrySelect Journal website
Volume:
3
Issue:
45
Pages:
12824-12829
Publication date:
2018-12-04
Acceptance date:
2018-11-19
DOI:
ISSN:
2365-6549
Source identifiers:
952946
Keywords:
Pubs id:
pubs:952946
UUID:
uuid:7884b530-3723-4a69-8731-c884ef8e6a9d
Local pid:
pubs:952946
Deposit date:
2018-12-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP