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Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation.

Abstract:

Treatment of cells with cytokines and growth factors leads to the synthesis of Suppressor of Cytokine Signalling (SOCS) proteins that act as potent negative regulators of signalling via the Jak/STAT pathway. We used immunohistochemistry to identify cells and pathologies where SOCS3 expression might influence acute and chronic inflammatory responses in human tissues. Epitope and GFP tagged SOCS3 fusion proteins were localised predominantly in the nucleus of transfected cells and a validated an...

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Publication status:
Published

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Publisher copy:
10.1007/s10735-011-9317-7

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of molecular histology
Volume:
42
Issue:
2
Pages:
137-151
Publication date:
2011-04-01
DOI:
EISSN:
1567-2387
ISSN:
1567-2379
Source identifiers:
120199

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