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Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents

Abstract:

KEY POINTS:There are two subtypes of trimeric intracellular cation (TRIC) channels but their distinct single-channel properties and physiological regulation have not been characterized. We examined the differences in function between native skeletal muscle sarcoplasmic reticulum (SR) K+ -channels from wild-type (WT) mice (where TRIC-A is the principal subtype) and from Tric-a knockout (KO) mice that only express TRIC-B. We find that lone SR K+ -channels from Tric-a KO mice have a lower open p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/JP277241

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-5647-6791
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-0960-683X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Japan Society for the Promotion of Science More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
597
Issue:
10
Pages:
2691-2705
Publication date:
2019-03-25
Acceptance date:
2019-03-20
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pmid:
30907436
Source identifiers:
991220
Language:
English
Keywords:
Pubs id:
pubs:991220
UUID:
uuid:78a05160-44d3-49ba-9ea9-765c0f0ef3d8
Local pid:
pubs:991220
Deposit date:
2019-05-02

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