Journal article
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase.
- Abstract:
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Atrial fibrillation (AF) is a growing public health burden, and its treatment remains a challenge. AF leads to electrical remodeling of the atria, which in turn promotes AF maintenance and resistance to treatment. Although remodeling has long been a therapeutic target in AF, its causes remain poorly understood. We show that atrial-specific up-regulation of microRNA-31 (miR-31) in goat and human AF depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay and alters nNOS subcel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 2.4MB)
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- Publisher copy:
- 10.1126/scitranslmed.aac4296
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 8
- Issue:
- 340
- Pages:
- 340ra74
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-04-22
- DOI:
- EISSN:
-
1946-6242
- ISSN:
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1946-6234
- Pmid:
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27225184
- Source identifiers:
-
624186
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:624186
- UUID:
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uuid:78b757aa-14ed-4a3a-b386-63764197005f
- Local pid:
- pubs:624186
- Deposit date:
- 2018-03-07
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from the American Association for the Advancement of Science at: http://dx.doi.org/10.1126/scitranslmed.aac4296
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