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A feasibility study of quantifying longitudinal brain changes in herpes simplex virus (HSV) encephalitis using magnetic resonance imaging (MRI) and stereology

Abstract:

Objectives To assess whether it is feasible to quantify acute change in temporal lobe volume and total oedema volumes in herpes simplex virus (HSV) encephalitis as a preliminary to a trial of corticosteroid therapy. Methods The study analysed serially acquired magnetic resonance images (MRI), of patients with acute HSV encephalitis who had neuroimaging repeated within four weeks of the first scan. We performed volumetric measurements of the left and right temporal lobes and of cerebral oedema...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0170215

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Grant:
improvingtheoutcomeofviralencephalitis,RP-PG-0108-10048
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
1
Article number:
e0170215
Publication date:
2017-01-26
Acceptance date:
2017-01-02
DOI:
ISSN:
1932-6203
Source identifiers:
680534
Keywords:
Pubs id:
pubs:680534
UUID:
uuid:78df8686-3d84-4189-9f0f-1e3cddb275e8
Local pid:
pubs:680534
Deposit date:
2017-02-24

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