Journal article
Mutant ACVR1 arrests glial cell differentiation to drive tumorigenesis in pediatric gliomas
- Abstract:
-
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone H3-encoding genes. The oncogenic mechanisms of action of ACVR1 mutations are currently unknown. Using mouse models, we demonstrate that Acvr1 G328V arrests the differentiation of oligodendroglial lineage cells, and cooperates with Hist1h3b K27M and Pik3ca H1047R to generate hig...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.ccell.2020.02.002
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cancer Cell Journal website
- Volume:
- 37
- Issue:
- 3
- Pages:
- 308-323
- Publication date:
- 2020-03-05
- Acceptance date:
- 2020-02-04
- DOI:
- EISSN:
-
1878-3686
- ISSN:
-
1535-6108
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1093282
- Local pid:
- pubs:1093282
- Deposit date:
- 2020-03-12
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Inc.
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