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Regulation of E2F1 by PAD4 mediated citrullination

Abstract:

Peptidyl arginine deiminase (PAD) 4 is a nuclear enzyme that converts arginine residues to citrulline. PAD4 activity has been implicated in inflammatory disease and cancer, although its mechanism of action, particularly the identity of functionally relevant targets, remains unclear. Moreover, there are no known reader domains specifically recognising citrulline modifications. E2F transcription factors play a central role in regulating gene expressio...

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Division:
MSD
Department:
Oncology
Role:
Supervisor
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Funding agency for:
La Thangue, N
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:7ad98e9b-ba63-497a-996b-775494322d21
Deposit date:
2016-10-02

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