Thesis
Investigation into pathophysiological mechanisms that alter ryanodine receptor function in cardiovascular disease
- Abstract:
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Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is a highly malignant cardiac disease caused by mutations to the cardiac ryanodine receptor (RyR2). Mutations at RyR2, including the V2475F mutation, lead to inappropriate diastolic Ca2+ release thereby triggering arrhythmogenesis and sudden cardiac death (SCD).
In order to identify specific alterations to RyR2 caused by the V2475F mutation, this research utilised native RyR2 channels derived from heter...
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Funding
+ British Heart Foundation
More from this funder
Grant:
BHF-FS/16/59/32735
Funder identifier:
http://dx.doi.org/10.13039/501100000274
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-09-02
Related Items
Terms of use
- Copyright holder:
- Wilson, A
- Copyright date:
- 2020
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