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Thesis

Investigation into pathophysiological mechanisms that alter ryanodine receptor function in cardiovascular disease

Abstract:

Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is a highly malignant cardiac disease caused by mutations to the cardiac ryanodine receptor (RyR2). Mutations at RyR2, including the V2475F mutation, lead to inappropriate diastolic Ca2+ release thereby triggering arrhythmogenesis and sudden cardiac death (SCD).

In order to identify specific alterations to RyR2 caused by the V2475F mutation, this research utilised native RyR2 channels derived from heter...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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