The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics.

Journal article

PURPOSE OF REVIEW: Atherosclerosis is an inflammatory disease process. This review discusses the recent genetic evidence from animal models and human populations that highlight the importance of chemokines in atherosclerosis. RECENT FINDINGS: CC-chemokine/CC-chemokine receptors (CCR), including CCR2/ MCP-1 (monocyte chemoattractant protein-1) and CCR5/RANTES (regulated on activation, normal T-cell expressed and secreted), have been shown in animal knockout and transgenic studies to have sign...

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Authors: Bursill, C; Channon, K; Greaves, D

• Publication status: Published
• Journal: Current opinion in lipidology
• Volume: 15
• Issue: 2
• Pages: 145-149
• Publication date: 2004-04-01
• DOI: 10.1097/00041433-200404000-00007
• EISSN: 1473-6535
• ISSN: 0957-9672
• Language: English
• Keywords: Chemokine CX3CL1; Polymorphism, Genetic; Genetics, Population; Arteriosclerosis; Models, Animal; Chemokines; Chemokines, CX3C; Receptors, Cytokine; Receptors, HIV; Mice; Membrane Proteins; Animals; Humans