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Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank

Abstract:

Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents including human herpes, hepatitis, polyoma, papilloma, and retroviruses, as well as Chlamydia trachomatis, Helicobacter pylori and Toxoplasma gondii, then assayed a random subset of 9695 UK Biobank partic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-022-29307-3

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-4502-2209
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
13
Article number:
1818
Publication date:
2022-04-05
Acceptance date:
2022-03-04
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1246854
Local pid:
pubs:1246854
Deposit date:
2022-03-22

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