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Thesis

Elucidating the effects of DNA modification on transcription

Abstract:

DNA modifications play important roles in genome function of vertebrates. 5-methylcytosine (mC) has been extensively studied over the last 50 years as the most common covalent DNA modification, present at roughly 70% of CpGs in the human genome. At promoters it is mostly associated with silencing of genes. An oxidative product of mC, 5-hydroxymethylcytosine (hmC), was found to be common in brain cells in 2007, and studies have attempted to elucidate the function of this stable modification...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Oxford college:
Magdalen College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Supervisor
ORCID:
0000-0002-2273-5994
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Supervisor
ORCID:
0000-0002-8892-5133
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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