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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Abstract:

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nature20784

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Journal website
Volume:
541
Issue:
7635
Pages:
81-86
Publication date:
2016-12-01
Acceptance date:
2016-11-10
DOI:
ISSN:
1476-4687
Source identifiers:
667202
Language:
English
Keywords:
Pubs id:
pubs:667202
UUID:
uuid:7c3b9acf-c34e-488e-ab8e-29431418d645
Local pid:
pubs:667202
Deposit date:
2017-03-02

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