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Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa

Abstract:
Background Population suppression gene drive has been proposed as a strategy for malaria vector control. A CRISPR-Cas9-based transgene homing at the doublesex locus (dsxFCRISPRh) has recently been shown to increase rapidly in frequency in, and suppress, caged laboratory populations of the malaria mosquito vector Anopheles gambiae. Here, problem formulation, an initial step in environmental risk assessment (ERA), was performed for simulated field releases of the dsxFCRISPRh tr... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-021-03674-6

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Role:
Author
ORCID:
0000-0002-7033-3463
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Role:
Author
ORCID:
0000-0001-8964-1784
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Role:
Author
ORCID:
0000-0001-8921-7422
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Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
20
Issue:
1
Article number:
170
Publication date:
2021-03-29
Acceptance date:
2021-02-25
DOI:
EISSN:
1475-2875

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