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Journal article

The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

Abstract:

OBJECTIVE: HLA-DRB1, a major genetic determinant of susceptibility to rheumatoid arthritis (RA), is located within 1,000 kb of the gene encoding tumor necrosis factor (TNF). Because certain HLA-DRB1*04 subtypes increase susceptibility to RA, investigation of the role of the TNF gene is complicated by linkage disequilibrium (LD) between TNF and DRB1 alleles. By adequately controlling for this LD, we aimed to investigate the presence of additional major histocompatibility complex (MHC) suscept...

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Publication status:
Published

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Publisher copy:
10.1002/art.10719

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Arthritis and rheumatism
Volume:
48
Issue:
1
Pages:
90-96
Publication date:
2003-01-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Source identifiers:
108492
Language:
English
Keywords:
Pubs id:
pubs:108492
UUID:
uuid:7d1609ac-294e-4102-b0c4-aa69ea1e1f52
Local pid:
pubs:108492
Deposit date:
2012-12-19

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