The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype.

Journal article

OBJECTIVE: HLA-DRB1, a major genetic determinant of susceptibility to rheumatoid arthritis (RA), is located within 1,000 kb of the gene encoding tumor necrosis factor (TNF). Because certain HLA-DRB1*04 subtypes increase susceptibility to RA, investigation of the role of the TNF gene is complicated by linkage disequilibrium (LD) between TNF and DRB1 alleles. By adequately controlling for this LD, we aimed to investigate the presence of additional major histocompatibility complex (MHC) suscept...

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Authors: Newton, J; Brown, M; Milicic, A; Ackerman, H; Darke, C

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 48
• Issue: 1
• Pages: 90-96
• Publication date: 2003-01-01
• DOI: 10.1002/art.10719
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: HLA-DR Antigens; Haplotypes; Lymphotoxin-alpha; Family Health; Arthritis, Rheumatoid; Humans; Case-Control Studies; Genetic Predisposition to Disease; HLA-DRB1 Chains; Tumor Necrosis Factor-alpha