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Peptide targeting by spontaneous isopeptide bond formation

Abstract:

Peptide fusion tags are fundamental for the identification, detection, and capture of proteins in biological assays. Commonly used peptide fusion tags rely on temporary non-covalent interactions for binding, which can put constraints on assay sensitivity. Here, peptide fusion tags were developed that could specifically interact with protein binding partners via spontaneous and irreversible isopeptide bond formation. To develop covalently interacting peptide-protein pairs, outer-membrane prote...

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Institution:
University of Oxford
Research group:
Dr. Mark Howarth
Oxford college:
St Peter's College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
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Funding agency for:
Bijan Zakeri
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:7d433538-0fa5-4081-acc5-06c1a77be322
Local pid:
ora:6132

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