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Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12

Abstract:

Background: Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflammatory cytokines, and haemozoin-containing leucocytes was studied in children with severe falciparum malarial anaemia. Methods: Twenty-six children with a primary diagnosis of severe malarial anaemia with any asexual Plasmodium falciparum

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-5-101

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
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Institution:
"KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya"
Role:
Author
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Institution:
"University of Oxford", "KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Institution:
"University of Oxford", "KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya"
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Institution:
"University of Oxford", "KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya"
Department:
Medical Sciences Division - Paediatrics,Department of
Role:
Author
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Funding agency for:
Casals-Pascual, C
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
5
Article number:
101
Publication date:
2006-11-01
DOI:
ISSN:
1475-2875
Language:
English
Subjects:
UUID:
uuid:7d5c724a-4767-4e24-91be-468e0be6722b
Local pid:
ora:3078
Deposit date:
2009-11-25

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