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Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.

Abstract:

Several inwardly-rectifying (Kir) potassium channels (Kir1.1, Kir4.1 and Kir4.2) are characterised by their sensitivity to inhibition by intracellular H(+) within the physiological range. The mechanism by which these channels are regulated by intracellular pH has been the subject of intense scrutiny for over a decade, yet the molecular identity of the titratable pH-sensor remains elusive. In this study we have taken advantage of the acidic intracellular environment of S. cerevisiae and used a...

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Publication status:
Published

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Publisher copy:
10.4161/chan.4.5.13006

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
Channels (Austin, Tex.)
Volume:
4
Issue:
5
Pages:
390-397
Publication date:
2010-01-01
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
Source identifiers:
66124
Language:
English
Keywords:
Pubs id:
pubs:66124
UUID:
uuid:7dc67521-3e8d-4a6d-9ff9-6ee01094b97d
Local pid:
pubs:66124
Deposit date:
2012-12-19

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