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Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei

Abstract:

The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. Here, we performed genome-wide association studies for genetic determinants of environmental and human adaptation using a combined dataset of 1,010 whole genome sequences of B. pseudomallei f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-019-0678-x

Authors


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Institution:
University of Oxford
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-1313-4011
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Role:
Author
ORCID:
0000-0002-4958-2166
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Grant:
098051
089275/Z/09/Z
106698/B/14/Z
106698/B/14/Z
Publisher:
Springer Nature Publisher's website
Journal:
Communications Biology Journal website
Volume:
2
Issue:
2019
Article number:
428
Publication date:
2019-11-22
Acceptance date:
2019-11-04
DOI:
EISSN:
2399-3642
Pmid:
31799430
Source identifiers:
1077027
Language:
English
Pubs id:
pubs:1077027
UUID:
uuid:7dfa22ac-6eec-40ee-ba6e-39f824face0f
Local pid:
pubs:1077027
Deposit date:
2020-01-07

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