Thesis
The cell cycle and DNA damage-dependent regulation of Cdt1 in schizosaccharomyces pombe
- Abstract:
-
Cdt1 is a conserved and essential eukaryotic protein that is required for the licensing step of DNA replication. In order to control replication licensing and ensure a single round of DNA replication occurs per cell cycle, Cdt1 is subject to strict regulation. In Metazoa and S. pombe, Cdt1 is targeted for ubiquitylation and proteolysis in S phase and after DNA damage by the CRL4Cdt2 ubiquitin ligase. CRL4Cdt2 is activated in Metazoa by an unusual mechanism that requires an interaction betw...
Expand abstract
Actions
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Shepherd, M
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:7f2ebafb-7d0d-4c0d-b6a6-277025f71850
- Local pid:
- ora:7238
- Deposit date:
- 2013-09-02
Terms of use
- Copyright holder:
- Shepherd, M
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available in ORA.
If you are the owner of this record, you can report an update to it here: Report update to this record