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Thesis

The cell cycle and DNA damage-dependent regulation of Cdt1 in schizosaccharomyces pombe

Abstract:

Cdt1 is a conserved and essential eukaryotic protein that is required for the licensing step of DNA replication. In order to control replication licensing and ensure a single round of DNA replication occurs per cell cycle, Cdt1 is subject to strict regulation. In Metazoa and S. pombe, Cdt1 is targeted for ubiquitylation and proteolysis in S phase and after DNA damage by the CRL4Cdt2 ubiquitin ligase. CRL4Cdt2 is activated in Metazoa by an unusual mechanism that requires an interaction betw...

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
Hertford College
Role:
Author

Contributors

Division:
MPLS
Department:
Zoology
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:7f2ebafb-7d0d-4c0d-b6a6-277025f71850
Local pid:
ora:7238
Deposit date:
2013-09-02

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