Thesis
Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy
- Abstract:
-
High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzymes, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFK-2/FBPase-2:PFKFB1-4). These are potential anti-tumour targets, but their individual and collective role requires further investigation.
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Authors
Contributors
+ Harris, A
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
+ Russell, A
Division:
MPLS
Department:
History Faculty
Sub department:
Archaeology Research Lab
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:7f47d9bb-7a9d-4dbc-92fa-57d2654640d1
- Local pid:
- ora:12306
- Deposit date:
- 2015-10-12
Terms of use
- Copyright holder:
- Williams, J
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available via ORA.
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