Thesis icon

Thesis

In vivo assessment of substrate utilisation in the hypertrophied heart; the role of glycolysis and glucose oxidation in hypertrophic progression

Abstract:

The work in this thesis investigates the role of glycolysis and glucose oxidation and the effects of metabolic modulation on the development of left ventricular hypertrophy (LVH) in the abdominal aortic constriction (AC) model.

Hypertrophy was induced via the surgical constriction of the abdominal aorta (AC) and through the combined use of cine MRI and dynamic nuclear polarization (DNP), hypertrophic development and progression was assessed. A 17 % increase in LV mass was obser...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:7f66f1d5-599a-4dca-9c64-0d46bf025e42
Deposit date:
2017-10-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP