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Immunopeptidomic profiling of HLA-A2-positive triple negative breast cancer identifies potential immunotherapy target antigens

Abstract:

The recent development in immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cells in the treatment of cancer has not only demonstrated the potency of utilising T-cell reactivity for cancer therapy, but has also highlighted the need for developing new approaches to discover targets suitable for such novel therapeutics. Here we analysed the immunopeptidomes of 6 HLA-A2-positive triple negative breast cancer (TNBC) samples by nano-ultra performance liquid chromatography tandem m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/pmic.201700465

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
ORCID:
0000-0002-9283-0743
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Funding agency for:
Olde Nordkamp, M
Grant:
2012NovemberPR004
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Funding agency for:
Anderson, A
Grant:
2012NovemberPR004
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Funding agency for:
Li, D
Grant:
C10396/A21667
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Funding agency for:
Kessler, B
Grant:
2012NovemberPR004
More from this funder
Funding agency for:
Li, D
Grant:
C10396/A21667
Publisher:
Wiley Publisher's website
Journal:
Proteomics Journal website
Volume:
18
Issue:
12
Article number:
1700465
Publication date:
2018-05-22
Acceptance date:
2018-05-11
DOI:
EISSN:
1615-9853
ISSN:
1615-9861
Pmid:
29786170
Language:
English
Keywords:
Pubs id:
pubs:853719
UUID:
uuid:7f986a73-f7c2-431d-a2a6-63084f58ce2c
Local pid:
pubs:853719
Deposit date:
2018-05-30

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