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Changing metabolism in differentiating cardiac progenitor cells - can stem cells become metabolically flexible cardiomyocytes?

Abstract:

The heart is a metabolic omnivore and the adult heart selects the substrate best suited for each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand of the contracting myocardium. The fetal heart exists in an hypoxic environment and obtains the bulk of its energy via glycolysis. After birth, the “fetal switch” to oxidative metabolism of glucose and fatty acids has been linked to the loss of the regenerative phenotype. Various stem cell types have been ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcvm.2018.00119

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Pembroke College
Role:
Author
ORCID:
0000-0003-0102-5261
More from this funder
Funding agency for:
Malandraki-Miller, S
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cardiovascular Medicine Journal website
Volume:
5
Pages:
119
Publication date:
2018-09-19
Acceptance date:
2018-08-10
DOI:
EISSN:
2297-055X
Source identifiers:
904464
Keywords:
Pubs id:
pubs:904464
UUID:
uuid:801f1a3a-8fc5-4fa5-b464-a1c0ac42e99e
Local pid:
pubs:904464
Deposit date:
2018-08-10

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