Changing metabolism in differentiating cardiac progenitor cells - can stem cells become metabolically flexible cardiomyocytes?
The heart is a metabolic omnivore and the adult heart selects the substrate best suited for each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy demand of the contracting myocardium. The fetal heart exists in an hypoxic environment and obtains the bulk of its energy via glycolysis. After birth, the “fetal switch” to oxidative metabolism of glucose and fatty acids has been linked to the loss of the regenerative phenotype. Various stem cell types have been ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.6MB)
- Publisher copy:
- Copyright holder:
- Malandraki-Miller et al
- Copyright date:
© 2018 Malandraki-Miller, Lopez, Al-Siddiqi and Carr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction
in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record