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Testing models of mRNA localization reveals robustness regulated by reducing transport between cells

Abstract:

Robust control of gene expression in both space and time is of central importance in the regulation of cellular processes and for multicellular development. However, the mechanisms by which robustness is achieved are generally not identified or well understood. For example, messenger RNA (mRNA) localization by molecular motor-driven transport is crucial for cell polarization in numerous contexts, but the regulatory mechanisms that enable this process to take place in the face of noise or sign...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2019.10.025

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-6304-9333
Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
117
Issue:
11
Pages:
2154-2165
Publication date:
2019-12-03
Acceptance date:
2019-10-15
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
1063251
Language:
English
Keywords:
Pubs id:
pubs:1063251
UUID:
uuid:808336c0-8ce5-4c98-a084-87d6b0fa9a3c
Local pid:
pubs:1063251
Deposit date:
2019-10-16

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